Cann is a surname. Notable people with the surname include:
Adrian Cann, Canadian soccer player
Alan Cann (born 1971), Australian rugby league footballer
Billy Cann (1882–1958), Australian rugby league footballer
David Cann, British actor
George Cann, Australian politician
George Cann, Australian herpetologist and snakeman
Harry Cann, British footballer
Howard Cann, American basketball coach
Jamie Cann, British politician
Kid Cann, American gangster
Rebecca L. Cann, geneticist
Robert Cann (disambiguation), several people
Sally Cann, birth name of the English presenter Sally James (presenter)
Warren Cann, Canadian drummer
William Cann, birth name of the American actor William Conrad
William Derwood Cann, Jr., American military officer and politician