Classification Sulfonic acid | ||
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Camphorsulfonic acid, sometimes abbreviated CSA or 10-CSA is an organosulfur compound. Like typical sulfonic acids, it is a relatively strong acid that is a colorless solid at room temperature and is soluble in water and a wide variety of organic substances.
This compound is commercially available. It can be prepared by sulfonation of camphor with sulfuric acid and acetic anhydride:
In organic synthesis, CSA and its derivatives can be used as resolving agents for chiral amines and other cations. For example, 3-bromocamphor-8-sulfonic acid was used in the synthesis of enantiopure devazepide.
Camphorsulfonic acid is used in some pharmaceutical formulations, where is it referred to as camsilate or camsylate, including trimetaphan camsilate and lanabecestat camsylate.