Neha Patil (Editor)

Caldesmon

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Species
  
Human

Entrez
  
800

Human
  
Mouse

Ensembl
  
ENSG00000122786

Caldesmon

Aliases
  
CALD1, CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22, caldesmon 1

External IDs
  
HomoloGene: 137424 GeneCards: CALD1

Caldesmon is a protein that in humans is encoded by the CALD1 gene.

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Immunochemistry

In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

References

Caldesmon Wikipedia