Calcagno is an Italian surname. Notable people with the surname include:
Domenico Calcagno (born 1943), Italian cardinalEric Calcagno (born 1967), Argentine sociologist, journalist, diplomat and politicianFrancesco Calcagno (1528–1550), Franciscan friarGiuseppa Bolognara Calcagno (1826–1884), Italian revolutionaryLawrence Calcagno (1913–1993), American painterRaimundo Calcagno (1906–1982), Argentine film critic, journalist and screenwriterRobert Calcagno (born 1960), Monegasque politicianUmberto Calcagno (born 1970), Italian footballer