Harman Patil (Editor)

Cadherin cytoplasmic region

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Symbol
  
Cadherin_C

InterPro
  
IPR000233

SUPERFAMILY
  
1i7w

Pfam
  
PF01049

SCOP
  
1i7w

Pfam
  
structures

Cadherin cytoplasmic region

In molecular biology, the cadherin cytoplasmic region is a conserved region found at the C-terminus of cadherin proteins. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region (the part of the cytoplasmic region which is adjacent to the transmembrane domain) of the cadherin. This region induces clustering and also binds to the protein catenin (p120ctn). The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton.

References

Cadherin cytoplasmic region Wikipedia