Species Human Entrez 23373 | Human Mouse Ensembl ENSG00000105662 | |
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Aliases CRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1 External IDs MGI: 2142523 HomoloGene: 41607 GeneCards: CRTC1 | ||
CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene. It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands and various regions of the adult central nervous system.
Clinical significance
Production of CRTC1 is blocked in Alzheimer's disease. TORC1 might be the target protein in ketamin induced anti-depressent effect via NMDA-antagonisation.
References
CRTC1 Wikipedia(Text) CC BY-SA