Suvarna Garge (Editor)

CORO1B

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Symbol
  
CORO1B

HUGO
  
2253

RefSeq
  
NM_020441

Entrez
  
57175

OMIM
  
609849

UniProt
  
Q9BR76

Coronin, actin binding protein, 1B also known as CORO1B is a protein which in humans is encoded by the CORO1B gene. Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility.

Function

A mammalian coronin enriches at the leading edge of migrating cells. Studies related to this protein are as follows:

  • Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.
  • F-actin binding is essential for coronin 1B function in vivo.
  • Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
  • Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
  • In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.
  • Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.
  • References

    CORO1B Wikipedia


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