Samiksha Jaiswal (Editor)

COPA (gene)

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Species
  
Human

Entrez
  
1314

Human
  
Mouse

Ensembl
  
ENSG00000122218

COPA (gene)

Aliases
  
COPA, HEP-COP, AILJK, coatomer protein complex subunit alpha

External IDs
  
MGI: 1334462 HomoloGene: 3218 GeneCards: COPA

Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.

Contents

Function

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.

Interactions

COPA (gene) has been shown to interact with COPE and COPB1.

References

COPA (gene) Wikipedia