Species Human Entrez 51208 | Human Mouse Ensembl ENSG00000066405 | |
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Aliases CLDN18, SFTA5, SFTPJ, claudin 18 External IDs MGI: 1929209 HomoloGene: 9489 GeneCards: CLDN18 | ||
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells . [supplied by OMIM]
Clinical significance
Isoform 2 (Claudin 18.2) is abundant in gastric tumors.
Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.
References
CLDN18 Wikipedia(Text) CC BY-SA