Kalpana Kalpana (Editor)

CLDN11

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Species
  
Human

Entrez
  
5010

Human
  
Mouse

Ensembl
  
ENSG00000013297

CLDN11

Aliases
  
CLDN11, OSP, OTM, claudin 11

External IDs
  
MGI: 106925 HomoloGene: 4093 GeneCards: CLDN11

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins.

The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.

References

CLDN11 Wikipedia