Entrez 5010 | Ensembl ENSG00000013297 | |
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Aliases CLDN11, OSP, OTM, claudin 11 External IDs MGI: 106925 HomoloGene: 4093 GeneCards: CLDN11 |
Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins.
The protein encoded by this gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.
References
CLDN11 Wikipedia(Text) CC BY-SA