Entrez 9793 | Ensembl ENSG00000175216 | |
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Aliases CKAP5, CHTOG, MSPS, TOG, TOGp, ch-TOG, cytoskeleton associated protein 5 External IDs MGI: 1923036 HomoloGene: 8844 GeneCards: CKAP5 | ||
Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog.
It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.
Interactions
CKAP5 has been shown to interact with TACC1.
References
CKAP5 Wikipedia(Text) CC BY-SA