Kalpana Kalpana (Editor)

CDC25C

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Species
  
Entrez
  
995

Human
  
Ensembl
  
ENSG00000158402

CDC25C

Aliases
  
CDC25C, CDC25, PPP1R60, cell division cycle 25C

External IDs
  
MGI: 88350 HomoloGene: 1356 GeneCards: CDC25C

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

Interactions

CDC25C has been shown to interact with MAPK14, CHEK1, PCNA, PIN1, PLK3 and NEDD4.

References

CDC25C Wikipedia


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