Species Human Entrez 8555 | Human Mouse Ensembl ENSG00000081377 | |
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Aliases CDC14B, CDC14B3, Cdc14B1, Cdc14B2, hcell division cycle 14B External IDs MGI: 2441808 HomoloGene: 104197 GeneCards: CDC14B | ||
Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.
Interactions
CDC14B has been shown to interact with p53. However, this interaction has not been reported in other studies.