Symbol FCGR2A Entrez 2212 OMIM 146790 | Alt. symbols FCG2, FCGR2A1, FCGR2 HUGO 3616 RefSeq NM_021642 | |
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CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.
It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body. Monoclonal antibodies can distinguish between CD32A and CD32B.
References
CD32 Wikipedia(Text) CC BY-SA