Species Human Entrez 80381 | Human Mouse Ensembl ENSG00000103855 | |
Aliases CD276, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2, CD276 molecule External IDs MGI: 2183926 HomoloGene: 11892 GeneCards: CD276 | ||
CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.
Function
Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM]
CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271.
References
CD276 Wikipedia(Text) CC BY-SA