Kalpana Kalpana (Editor)

CD120

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Symbol
  
TNFRSF1A

Entrez
  
7132

OMIM
  
191190

Alt. symbols
  
CD120a, TNFR1

HUGO
  
11916

RefSeq
  
NM_001065

CD120

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

  • CD120a - TNFR1 - TNFR superfamily member 1A
  • CD120b - TNFR2 - TNFR superfamily member 1B
  • TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior, and is involved in neurotoxic processes. Elevated levels of TNFR1 has been found in severe mental disorders.

    References

    CD120 Wikipedia