CD-200 is a cell surface receptor that is thought to act in transplantation to prevent the rejection of grafts, such as skin grafts upon ligation of CD-200 receptor on myeloid cells
The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.
It is currently under research by Dr. Reginald M. Gorcyznski at the University Health Network.
References
CD-200 Wikipedia(Text) CC BY-SA