Neha Patil (Editor)

CCNF

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Human

Entrez
  
899

Human
  
Mouse

Ensembl
  
ENSG00000162063

CCNF

Aliases
  
CCNF, FBX1, FBXO1, cyclin F

External IDs
  
MGI: 102551 HomoloGene: 1335 GeneCards: CCNF

G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene.

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.

References

CCNF Wikipedia