Byrnes is a surname. Notable people with the surname include:
Edd Byrnes, American actor
Esther Byrnes (1867–1946), American biologist and science teacher
Garrett Byrnes, American composer
Gene Byrnes, American comic artist
James F. Byrnes, US politician and U.S. Secretary of State
John W. Byrnes, US politician
Jo Byrns, US politician
Josh Byrnes, manager of the Arizona Diamondbacks
Eric Byrnes, American baseball player
Kevin P. Byrnes, U.S. Army 4-star general
Norman Byrnes (botanist), Australian
Norman Byrnes (lawyer), American
Pat Byrnes, American cartoonist
Shannon Byrnes, Australian rules player
Steve Byrnes, television announcer and producer
Thomas F. Byrnes, 19th Century New York City police inspector
Thomas Joseph Byrnes, premier of Queensland
