EC number 1.3.99.2 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9027-88-7 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a butyryl-CoA dehydrogenase (EC 1.3.99.2) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are butyryl-CoA and an acceptor, whereas its two products are 2-butenoyl-CoA and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is butanoyl-CoA:acceptor 2,3-oxidoreductase. Other names in common use include butyryl dehydrogenase, unsaturated acyl-CoA reductase, ethylene reductase, enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase, butyryl coenzyme A dehydrogenase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, 3-hydroxyacyl CoA reductase, and butanoyl-CoA:(acceptor) 2,3-oxidoreductase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, valine, leucine and isoleucine degradation, and butanoate metabolism. It employs one cofactor, FAD.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1BUC and 1JQI.