Butyrate—CoA ligase

Updated on Oct 11, 2024

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EC number 6.2.1.2 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 9080-51-7 BRENDA BRENDA entry KEGG KEGG entry

In enzymology, a butyrate-CoA ligase, also known as XM-ligase, (EC 6.2.1.2) is an enzyme that catalyzes the chemical reaction

ATP + an acid + CoA ⇌ AMP + diphosphate + an acyl-CoA

The 3 substrates of this enzyme are ATP, acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme participates in butanoate metabolism.

Nomenclature

The systematic name of this enzyme class is butanoate:CoA ligase (AMP-forming). Other names in common use include:

butyryl-CoA synthetase, fatty acid thiokinase (medium chain),

acyl-activating enzyme, fatty acid elongate,

fatty acid activating enzyme,

fatty acyl coenzyme A synthetase,

medium chain acyl-CoA synthetase,

butyryl-coenzyme A synthetase,

L-(+)-3-hydroxybutyryl CoA ligase,

xenobiotic/medium-chain fatty acid ligase, and

short-chain acyl-CoA synthetase.

References

Butyrate—CoA ligase Wikipedia

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