Burkholder is a surname. Notable people with the surname include:
Celia Kay Burkholder or Celia Kaye (born 1941), American actress
Dave Burkholder (contemporary), Canadian college ice hockey coach
Donald Burkholder (1927–2013), American mathematician
James B. Burkholder (1918–2006), American army officer, activist for peace and social justice issues
Mabel Burkholder (1881–1973), Canadian historian and author
Max Burkholder (born 1997), American child voice actor
Seth Burkholder (born 1982), American football player
Steve Burkholder (contemporary), Republican politician from Colorado, mayor of Lakewood 1999–2007
Walter H. Burkholder (1898–1977), American plant pathologist
