Bruijn is a Dutch surname. Notable people with the surname include:
Antonie Augustus Bruijn, Dutch trader in naturalia and naturalist (1842-1890)
Chantal de Bruijn, Dutch field hockey player
Cornelis de Bruijn (1652-1727), Dutch artist and traveler
Inge de Bruijn, Dutch swimmer
Jordy Bruijn (born 1996), Dutch football player
Nicolaas Govert de Bruijn, Dutch mathematician
Pi de Bruijn, Dutch architect