Bru or Brú is the surname of the following people
Antonio Brú (born 1962), Spanish theoretical physicist
Claudio López Bru (1853–1925), Spanish businessman
Federico Laredo Brú (1875–1946), President of Cuba from 1936 to 1940
Francisco Bru (1885–1962), Spanish footballer, referee and manager
Heðin Brú (1901–1987), pen name of the Faroese novelist and translator Hans Jacob Jacobsen
Jon Bru (born 1977), Spanish professional road bicycle racer
Jonathan Bru (born 1985), Mauritian international footballer
Jørgen Bru (1881–1974), Norwegian sport shooter
Kévin Bru (born 1988), French-born Mauritian footballer
Luis Bru (1907–?), Spanish boxer
Luis Ortega Bru (1916–1982), Spanish sculptor and carver
Mosen Vicente Bru (1682–1703), Spanish painter
Myriam Bru (born 1932), French actress
Raymond Bru (1906–1989), Belgian fencer
Salvador Bru, Spanish painter
Tina Bru (born 1986), Norwegian politician
Yannick Bru (born 1973), French rugby union coach and former player