Brotherton is a surname. Notable people with the surname include:
Edward Brotherton, 1st Baron Brotherton, English businessman and politician
Helen Brotherton, English conservationist
John Brotherton, American actor
John Brotherton (industrialist) (1829–1917), innovative tube manufacturer who served as the 33rd Mayor of Wolverhampton 1883/84
Joseph Brotherton, English politician
Michael Brotherton, British journalist and politician
Simon Brotherton, British sports announcer
Thomas William Brotherton, British Army general
Thomas of Brotherton, 1st Earl of Norfolk
