Brewis is a surname. Notable people with the surname include:
Anne Brewis, daughter of Roundell Cecil Palmer, 3rd Earl of SelborneBobby Brewis, the last known human case of foot-and-mouth disease in BritainHannes Brewis (1920–2007), South African rugby union playerHenry Brewis (artist) (1932–2000), English artist and poetJohn Brewis, British politician and barristerPeter Brewis, British composer and musicianRobert Brewis, English footballerTom Brewis (1907–1975), English footballer