Brenes is a Spanish surname. Notable people with the surname include:
Abderramán Brenes (born 1978), Puerto Rican judoka
Bartosz Brenes (born 1989), Costa Rican DJ
Carlos Alberto Brenes (1884–1942), President of Nicaragua
Chico Brenes, Nicaraguan skateboarder
Édgar Brenes, Costa Rican architect
Humberto Brenes (born 1951), Costa Rican poker player
Eric Brenes, Costa Rican poker player
Nery Brenes (born 1985), Costa Rican sprinter
Oswaldo Brenes Álvarez (1942–2013), Costa Rican Roman Catholic bishop
Pablo Brenes (born 1982), Costa Rican footballer
Randall Brenes (born 1983), Costa Rican footballer
Roberto Brenes Mesén (1874–1947), Costa Rican politician, writer, educator, and journalist
Victor Brenes
