Brendel is a surname. Notable people with the surname include:
Alfred Brendel (born 1931), pianist
Brian Brendell (born 1986), Namibian footballer
El Brendel (1890–1964), American entertainer
Franz Brendel, 19th-century music critic and publisher
Jake Brendel (born 1992), American football player
Joachim Brendel (1921–1974), German Luftwaffe pilot
Karl Brendel (1871–1925), German sculptor
Otto Brendel (1901–1973), scholar of Etruscan art
Sarah Brendel, German pop singer
Wolfgang Brendel (born 1947), German opera singer
