Brendel is a surname. Notable people with the surname include:
Alfred Brendel (born 1931), pianistBrian Brendell (born 1986), Namibian footballerEl Brendel (1890–1964), American entertainerFranz Brendel, 19th-century music critic and publisherJake Brendel (born 1992), American football playerJoachim Brendel (1921–1974), German Luftwaffe pilotKarl Brendel (1871–1925), German sculptorOtto Brendel (1901–1973), scholar of Etruscan artSarah Brendel, German pop singerWolfgang Brendel (born 1947), German opera singer