Brändle or Brandle is a surname. Notable individuals with the surname include:
Daniel Brändle (born 1992), Liechtensteiner international footballer who plays as a midfielder
Joseph E. Brandle (1839–1909), American soldier who received the Medal of Honor during the American Civil War
Kurt Brändle (1912–1943), German Luftwaffe military aviator during World War II
Matthias Brändle (born 1989), Austrian professional road bicycle racer
Pola Brändle (born 1980), German artist