The boukólos rule is a phonological rule of the Proto-Indo-European language (PIE). It states that a labiovelar stop (*kʷ *gʷ *gʷʰ) dissimilates to an ordinary velar stop (*k *g *gʰ) next to the vowel *u or its corresponding glide *w. The rule is named after an example, the Ancient Greek word βουκόλος (boukólos) "cowherd", from PIE *gʷou-kolos < *gʷou-kʷolos. That the second constituent of this word was originally *-kʷolos can be seen from the analogously constructed αἰπόλος (aipólos) "goatherd" < *ai(ǵ)-kʷolos. The same dissimilated form *gʷou-kolos is the ancestor of Proto-Celtic *bou-koli-, the source of Welsh bugail (which would have had -b- rather than -g- if it had come from a form with *-kʷ-).
Another example could be the Greek negation οὐκ[ί] (ouk[í]), which Warren Cowgill has interpreted as coming from pre-Greek *ojukid < *(ne) oju kʷid, meaning approximately "not on your life". Without the boukólos rule, the result would have been **οὐτ[ί] (out[í]).
The rule is also found in Germanic, mainly in verbs, where labiovelars are delabialised by the epenthetic -u- inserted before syllabic resonants: