Botkin (Russian: Боткин) or Botkina (feminine; Боткина) is a common Russian or Scottish surname which may refer to:
Benjamin A. Botkin (1901–1975), American folklorist and scholar
Cordelia Botkin (1854–1910), American murderer
Daniel Botkin, author and environmentalist, son of Benjamin A. Botkin
Eugene Botkin (1865–1918), Russian court physician, father of Gleb and Tatiana
Gleb Botkin (1900–1969), novelist and founder of the Church of Aphrodite, son of Eugene Botkin
Jeremiah D. Botkin (1849–1921), U.S. Representative from Kansas
Kirk Botkin (born 1971), American football player who performed in the National Football League; college football coach
Mikhail Botkin (1839-1914), Russian artist
Perry Botkin Sr. (1907–1973), American jazz musician, composer and songwriter
Perry Botkin Jr. (born 1933), American composer, producer, arranger, and musician
Sean Botkin, American pianist
Sergey Botkin (1832–1889), Russian clinician and therapist
Vasily Botkin (1812-1869), critic and essayist, brother of Sergey Botkin
Tatiana Botkina (1898–1986), daughter of Russian court physician Eugene Botkin
Botkin, a man character from Rupert (TV series) in 1991 on "Rupert And The Twilight Fan" episode
V. Botkin, a character (limited almost entirely to an index entry) in Vladimir Nabokov's 1962 masterpiece "Pale Fire". Nabokov is said to have claimed that this Botkin was the author of the entire novel. If so, then Botkin is an alias for Nabokov himself.