Bothe is a surname. Notable people with the surname include:
Detlef Bothe (born 1957), East German sprint canoeist who competed in the mid-1970sDetlef Bothe (born 1965), German actorElsbeth Levy Bothe (born 1927), American attorney and judgeHans-Werner Bothe (born 1952), German philosopher and neurosurgeonHeinz-Jürgen Bothe (born 1941), German rower who competed for East Germany in the 1968 Summer OlympicsHerta Bothe (born 1921), female Nazi concentration camp guard imprisoned for war crimes, but eventually releasedIda Bothe, artist and educator in the 19th centuryRoger Bothe (born 1988), American soccer playerSabine Bothe (born 1960), German handball goalkeeperWalther Bothe (1891–1957), German nuclear physicist, shared the Nobel Prize in Physics in 1954 with Max Born