Bothe is a surname. Notable people with the surname include:
Detlef Bothe (born 1957), East German sprint canoeist who competed in the mid-1970s
Detlef Bothe (born 1965), German actor
Elsbeth Levy Bothe (born 1927), American attorney and judge
Hans-Werner Bothe (born 1952), German philosopher and neurosurgeon
Heinz-Jürgen Bothe (born 1941), German rower who competed for East Germany in the 1968 Summer Olympics
Herta Bothe (born 1921), female Nazi concentration camp guard imprisoned for war crimes, but eventually released
Ida Bothe, artist and educator in the 19th century
Roger Bothe (born 1988), American soccer player
Sabine Bothe (born 1960), German handball goalkeeper
Walther Bothe (1891–1957), German nuclear physicist, shared the Nobel Prize in Physics in 1954 with Max Born
