Boss is a surname. Notable people with the surname include:
Harley Boss (1908–1964), American baseball player and coachHugo Boss (fashion designer) (1885–1948)Isaac Boss (born 1980), Irish rugby union playerKevin Boss (born 1984), American football tight endLewis Boss (1846–1912), American astronomerMarcellus Boss (1901–1967), 5th Civilian Governor of GuamMedard Boss (1903–1990), Swiss psychoanalytic psychiatristTerry Boss (born 1981), Puerto Rican association football goalkeeper