Boss is a surname. Notable people with the surname include:
Harley Boss (1908–1964), American baseball player and coach
Hugo Boss (fashion designer) (1885–1948)
Isaac Boss (born 1980), Irish rugby union player
Kevin Boss (born 1984), American football tight end
Lewis Boss (1846–1912), American astronomer
Marcellus Boss (1901–1967), 5th Civilian Governor of Guam
Medard Boss (1903–1990), Swiss psychoanalytic psychiatrist
Terry Boss (born 1981), Puerto Rican association football goalkeeper
