Borthwick is a surname. Notable people with the surname include:
Alastair Borthwick
Algernon Borthwick, 1st Baron Glenesk
Bill Borthwick - see William Borthwick below
David Borthwick, Australian public servant
Jack Borthwick (1884–1948), Australian footballer
Jamie Borthwick
John Borthwick (footballer) (born 1964), English footballer
John Borthwick (veterinary surgeon) (1867–1936), veterinary surgeon in the Cape Colony, South Africa
Sir John Thomas Borthwick, 3rd Baronet (1917–2002) of the Borthwick baronets
John Borthwick, 5th Lord Borthwick (died 1566)
John Borthwick, 8th Lord Borthwick (died 1623)
John Borthwick, 9th Lord Borthwick (1616–1675) (dormant 1675)
John David Borthwick
John David Borthwick (1824–1892), Scottish journalist and author
John Henry Stuart Borthwick, 23rd Lord Borthwick (1905–1996) (confirmed in title 1986)
John Hugh Borthwick, 24th Lord Borthwick (born 1940)
Mamah Borthwick
Mark Borthwick
Peter Borthwick
Scott Borthwick
Stephen Borthwick (Headmaster of Epsom College)
Steve Borthwick, English international rugby union player
Walter Borthwick (born 1948), Scottish football player and manager