Boothe is a surname. Notable people with the surname include:
Armistead L. Boothe, American politician
Chris Boothe, fictional character from the soap opera Passions
Clare Boothe Luce, American author and politician
Demico Boothe, American author
Jill Kinmont Boothe, American skier
Ken Boothe, Jamaican singer
Kevin Boothe, American football player
Lorna Boothe, Jamaican born British athlete
Powers Boothe, American actor
Roger L. Boothe, Jr, American Highway Construction Executive