Boothe is a surname. Notable people with the surname include:
Armistead L. Boothe, American politicianChris Boothe, fictional character from the soap opera PassionsClare Boothe Luce, American author and politicianDemico Boothe, American authorJill Kinmont Boothe, American skierKen Boothe, Jamaican singerKevin Boothe, American football playerLorna Boothe, Jamaican born British athletePowers Boothe, American actorRoger L. Boothe, Jr, American Highway Construction Executive