Bloodworth is an English surname derived possibly from Blidworth in Nottinghamshire or from a similar toponym. Notable people with the surname include:
James Bloodworth Jr. (1925–2006), American physician and pathologistJimmy Bloodworth (1917–2002), American baseball playerMargaret Bloodworth, former Canadian National Security AdvisorRhoda Alice Bloodworth (1889–1980), New Zealand labour activist, community worker and feministSandra Bloodworth, Australian labour historian and socialist activistSir Thomas Bloodworth (1620–1682), English merchant and politician; Lord Mayor of London during the Great Fire of London (1666)Thomas Bloodworth (New Zealand politician) (1882–1974), New Zealand politicianTimothy Bloodworth (1736–1814), American teacher and statesman from North CarolinaLinda Bloodworth-Thomason (born 1947), American writer and television producer