Blassingame is a surname. Notable people with the surname include:
Jerel Blassingame (born 1981) American professional basketball player
John Wesley Blassingame (1940–2000), American historian and writer
Lurton Blassingame (1904–1988), American literary agent
William Blassingame (born 1836), American politician
Wyatt Rainey Blassingame (1909–1985), American author