Blakiston is a surname. Notable people with the surname include:
Bob Blakiston (1855-1918), American Major League Baseball outfielderCaroline Blakiston (1933-), English actressCharles Blakiston (1825–1898), New Zealand politicianHerbert Edward Douglas Blakiston (1862–1942), President of Trinity College, Oxford, Vice-Chancellor of Oxford UniversityJohn Blakiston (1603–1649), English MP, coal merchant and one of the regicides of King Charles IJohn Blakiston-Houston (1829-1920), Irish member of parliamentMatthew Blakiston (1702–1774), Lord Mayor of London, 1st Baronet of LondonNathaniel Blakiston, Royal Governor of the Maryland colony from 1698 to 1702Nehemiah Blakiston, Royal Governor of the Maryland colony from 1691 to 1692Oswell Blakeston, pseudonym of Henry Joseph Hasslacher (1907–1985), writer, artist and poetThomas Blakiston (1832-1891), English explorer and naturalist