Blakiston is a surname. Notable people with the surname include:
Bob Blakiston (1855-1918), American Major League Baseball outfielder
Caroline Blakiston (1933-), English actress
Charles Blakiston (1825–1898), New Zealand politician
Herbert Edward Douglas Blakiston (1862–1942), President of Trinity College, Oxford, Vice-Chancellor of Oxford University
John Blakiston (1603–1649), English MP, coal merchant and one of the regicides of King Charles I
John Blakiston-Houston (1829-1920), Irish member of parliament
Matthew Blakiston (1702–1774), Lord Mayor of London, 1st Baronet of London
Nathaniel Blakiston, Royal Governor of the Maryland colony from 1698 to 1702
Nehemiah Blakiston, Royal Governor of the Maryland colony from 1691 to 1692
Oswell Blakeston, pseudonym of Henry Joseph Hasslacher (1907–1985), writer, artist and poet
Thomas Blakiston (1832-1891), English explorer and naturalist