Blaine is a surname. Notable people with the surname include:
Barbara Blaine, founder and president of Survivors Network of those Abused by Priests (SNAP), a U.S. advocacy group for survivorsDan Blaine (1891–1958), American football player and National Football League team ownerDavid Blaine (born 1973), American illusionist and stunt performerEd Blaine (born 1940), American National Football League player and pharmaceutical researcherEphraim Blaine (1741–1804), early Pennsylvania settler and commissary-general in the Continental ArmyHal Blaine (born 1929), pop music drummerJames G. Blaine (1830–1893), American politician, Speaker of the United States House of RepresentativesJason Blaine (born 1980), Canadian country music singer and songwriterJerry Blaine (1910-1973), American bandleader, label owner, record distributor and singerJohn J. Blaine (1875–1934), United States Senator and Governor of WisconsinMarcie Blaine (born 1944), American singerNell Blaine (1922-1996), American landscape painter and watercoloristRobert Stickney Blaine (1816-1897), English politicianVivian Blaine (1921–1995), American actress and singerFictional characters include:
Richard "Rick" Blaine, protagonist of the 1942 film Casablanca, played by Humphrey Bogart