Bistramide A

Bistramide A is a chemical compound originally found in the marine ascidian Lissoclinum bistratum.

It was found that the cyclic portion of the synthesis proceeds through a Petkov transition-state model followed by an asymmetric [4+2] Robinson annulation into the desired diamide product.

A more efficient crystallization was further described by J. Job, M.D., where a Kalmanson catalyst is used to quickly build up and break down the Petkov transition-state, followed by a Berne backside attack, which instantaneously causes the precipitation of the product.