Samiksha Jaiswal (Editor)

Biotin—(methylmalonyl CoA carboxytransferase) ligase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
6.3.4.9

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
37318-66-4

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a biotin-[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9) is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase]

The 3 substrates of this enzyme are ATP, biotin, and [[apo-[methylmalonyl-CoA:pyruvate carboxytransferase]]], whereas its 3 products are AMP, diphosphate, and methylmalonyl-CoA:pyruvate carboxytransferase.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming). Other names in common use include biotin-[methylmalonyl-CoA-carboxyltransferase] synthetase, biotin-methylmalonyl coenzyme A carboxyltransferase synthetase, biotin-transcarboxylase synthetase, methylmalonyl coenzyme A holotranscarboxylase synthetase, biotin-[methylmalonyl-CoA-carboxyltransferase] ligase, biotin:apo[methylmalonyl-CoA:pyruvate carboxyltransferase] ligase, and (AMP-forming). This enzyme participates in biotin metabolism.

References

Biotin—(methylmalonyl-CoA-carboxytransferase) ligase Wikipedia


Similar Topics