Bignon is a surname. Notable people with the surname include:
Armand-Jérôme Bignon (1711–1772), French lawyer, royal librarian and conseiller d'ÉtatJean-Paul Bignon, (1662–1743), French ecclesiastic, statesman, writer, preacher, and librarian to Louis XIV of FranceJérôme Bignon (1589–1656), French lawyer born in ParisJérôme Bignon (politician) (born 1949), member of the National Assembly of FranceLouis Bignon (1816–1906), famous French chef whose Café Riche became the most fashionable in ParisLouis Pierre Édouard, Baron Bignon (1771–1841), French diplomat and historianAlexandre Bignon (1986-), French immunologist