Big Mac is a nickname of:
Enzo Maccarinelli (born 1980), Welsh former professional boxerJimmy Macullar (1855-1924), American Major League Baseball playerRobert MacPherson (BMX rider) (born 1971), retired BMX riderMassimo Maccarone (born 1979), Italian footballerAlex McDonald (prospector) (1859–1909), Canadian gold prospector who made and lost a fortune in the KlondikeJohn McEnroe (born 1959), retired professional tennis playerMark McGwire (born 1963), retired Major League Baseball playerJamie McMurray (born 1976), auto racing driver