Big Boy is the nickname of:
Arthur Crudup (1905–1976), American singer and guitarist
Big Boy Goudie (1899–1966), American jazz musician
Malcolm Sebastian (1923–2006), American comedian
Arthur "Big Boy" Spires (1912–1990), American blues singer and guitarist
Carlisle Towery (1920-2012), National Basketball Association and League player
Guinn "Big Boy" Williams (1899–1962), American actor
