Biflaviolin synthase

Biflaviolin synthase (EC 1.14.21.7, CYP158A2, CYP 158A2, cytochrome P450 158A2) is an enzyme with systematic name flaviolin,NADPH:oxygen oxidoreductase. This enzyme catalyses the following chemical reaction

(1) 2 flaviolin + NADPH + H⁺ + O₂ ⇌ 3,3'-biflaviolin + NADP⁺ + 2 H₂O(2) 2 flaviolin + NADPH + H⁺ + O₂ ⇌ 3,8'-biflaviolin + NADP⁺ + 2 H₂O

This cytochrome P450 enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyses a phenol oxidation C-C coupling reaction.