Puneet Varma (Editor)

Bicarbonate transporter protein

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Symbol
  
HCO3_cotransp

Pfam clan
  
CL0062

PROSITE
  
PDOC00192

Pfam
  
PF00955

InterPro
  
IPR011531

SCOP
  
1btr

Bicarbonate transporter protein

In molecular biology, bicarbonate transporter proteins are proteins which transport bicarbonate. Bicarbonate (HCO3 ) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO3 transport modes. Anion exchanger proteins exchange HCO3 for Cl in a reversible, electroneutral manner. Na+/HCO3 co-transport proteins mediate the coupled movement of Na+ and HCO3 across plasma membranes, often in an electrogenic manner. Na+ driven Cl/HCO3 exchange and K+/HCO3 exchange activities have also been detected in certain cell types, although the molecular identities of the proteins responsible remain to be determined.

Sequence analysis of the two families of HCO3 transporters that have been cloned to date (the anion exchangers and Na+/HCO3 co-transporters) reveals that they are homologous. This is not entirely unexpected, given that they both transport HCO3 and are inhibited by a class of pharmacological agents called disulphonic stilbenes. They share around ~25-30% sequence identity, which is distributed along their entire sequence length, and have similar predicted membrane topologies, suggesting they have ~10 transmembrane (TM) domains.

A conserved domain is found at the C terminus of many bicarbonate transport proteins. It is also found in some plant proteins responsible for boron transport. In these proteins it covers almost the entire length of the sequence.

The Band 3 anion exchange proteins that exchange bicarbonate are the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of this domain are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).

References

Bicarbonate transporter protein Wikipedia