Beta Phi Sigma (ΒΦΣ) refers to the first Pharmacy Fraternity in the United States. Beta Phi Sigma stands for Buffalo Pharmacy School. Originally organized by the graduating class of 1889 and 1890, Beta Phi Sigma grew from one chapter, Alpha, at the University at Buffalo to eleven chapters before World War II. The induction of so many males into the military decimated the ranks of Pharmacy students so that by the end of World War II Beta Phi Sigma ceased to exist.
The first chapter, Alpha, was reorganized at the University at Buffalo Pharmacy School. This chapter grew until 1973 when again because of the influx of women to the profession, and small number of men pledging the fraternity Beta Phi Sigma was dissolved.
There is still an alumni chapter that holds a reunion every 10 years, the first being held in 1997.