Besser is the surname of:
Chaskel Besser (born 1923), Rabbi from Manhattan
Joe Besser (1907–1988), American comedian
Les Besser, founder of Compact Software, the first RF and microwave EDA company
Matt Besser (born 1967), best known from the sketch comedy show Upright Citizens Brigade
Robert Dennis Besser, see Robert Denning
Wilibald Swibert Joseph Gottlieb von Besser (1784–1842), Austrian botanist
Jesse Besser, who invented a machine for making Besser blocks.